The Reactions of 3- Mercapto-6-Methyl- 1,2,4- Triazin-5(2H)-one with Alkyl Phosphites
نویسندگان
چکیده
The reaction of 3-mercapto-6-methyl-1, 2, 4-triazin-5 (2H)-one 1 with dimethyl 2a and trimethyl phosphite 3a at 100 C in absence of solvent yields the dimeric product 4 and while the alkylated products 5 and 6 are obtained for reaction with 3a. Methylation of 1 by methyl iodide gives alkylated product 5. Reaction of 1 with diethyl 2b and triethyl phosphite 3b by the same previous conditions yields phosphonate adduct 7 and while the acids 9a and 10 are obtained for reaction with 3b. Acid hydrolysis of phosphonate 7 regenerated the starting material 1. Reaction of 1 with diisopropyl 2c and triisopropyl phosphite 3c takes place only in presence of a base for 2c and a protonating agent for 3c respectively in dry toluene at reflux temperature to give phosphonate adduct 11 and the alkylated product 12 respectively. Reaction time is an important factor in these reactions. Possible reaction mechanisms are considered and structures of the new products were confirmed on the basis of spectral data, and elementary analysis.
منابع مشابه
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